1420477-60-6 Acalabrutinib

Melting point:>133 degree (dec.)
Density 1.37±0.1 g/cm3

solubility Soluble in DMSO (up to at least 25 mg/ml)
pka11.47±0.70

 

Acalabrutinib, a second-generation BTK inhibitor, is an irreversible BTK inhibitor primarily used for the treatment of mantle cell lymphoma. In February 2016, AstraZeneca acquired a 55% stake in AcertaPharma for $4 billion (while also owning the remaining 45% stake), thereby bringing Acalabrutinib under its umbrella. In October 2017, after being granted breakthrough therapy and accelerated approval, Acalabrutinib was approved by the FDA for use in mantle cell lymphoma patients who had previously received other therapies. In 2019, based on the Phase III clinical trials ELEVATE-TN and ASCEND, Acalabrutinib was approved for the treatment of adult patients with CLL or small cell lymphoma (SLL).

 

1420477-60-6

ACP-196

Acalabrutinib (ACP-196)

4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide

(S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

Benzamide, 4-(8-amino-3-((2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl)imidazo(1,5-a)pyrazin-1-yl)-N-2-pyridinyl-

(S)-4-(8-amino-3-(1-but-2-ynoylpyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(2-pyridyl)benzamide

(S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo(1,5-a)pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

4-(8-amino-3-((2S)-1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo(1,5-a)pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide; ACP 196

ACP-196;Acalabrutinib

 

 

 

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